Jonah Hex (Josh Brolin) is a scarred drifter and bounty hunter of last resort, a stoic, battle-hardened gunslinger who can track down anyone...and anything. Having survived death, Jonah's violent history is steeped in myth and legend, and has left him with one foot in the natural world and one on the "other side." A man fated to wander alone, his sole human connection is with Lilah (Megan Fox), whose life in a brothel has left her with scars of her own.

Jonah's past is about to catch up with him when the U.S. military makes him an offer he can't refuse: in exchange for freedom from the warrants on his head, he must track down and stop the sinister terrorist Quentin Turnbull (John Malkovich), the man who killed Hex's family and mutilated his face with a branding iron. Turnbull, who is gathering an army and preparing to unleash Hell, is also Jonah's oldest enemy and will stop at nothing until Jonah is dead.

Based on the legendary character from the comic book series from DC Comics, Jonah Hex is an epic action adventure about one man's personal quest for redemption against the canvas of the battle between good and evil.